THRESHOLD ANALYSIS AND PROGRAMS FOR PREVENTION OF HIV-INFECTION
THRESHOLD ANALYSIS AND PROGRAMS FOR PREVENTION OF HIV-INFECTION
复制标题
DOI：
10.1177/0272989x9501500402
复制
发表时间：
1995-10-01
影响因子：
3.6
通讯作者：
QUALLS, NL
中科院分区：
文献类型：
--
作者：
HOLTGRAVE, DR;QUALLS, NL
背景资料。在行为变化和健康结果评估方面，衡量艾滋病毒感染预防活动的经济效果提出了特殊挑战。方法：研究方法。解决这一困难的一种方法是使用阈值分析来确定避免每一次艾滋病毒感染的成本水平，如果超过这个水平，社会似乎不愿支付。作者使用成本效用分析框架来确定艾滋病毒预防计划的资金门槛，对基本情况结果进行敏感性分析，并将这些结果应用于疾病控制和预防中心1993财年用于外部艾滋病毒预防计划的预算。结果。以1993年美元计算，每避免一次艾滋病毒感染的成本门槛是417,000美元，范围从185,000美元到648,000美元，这取决于社会愿意为获得的每一个质量调整的生命年支付的美元金额。结论。对特定艾滋病毒感染预防活动的经济评估至少可以从确定其有效性水平是高于还是低于这一导出的货币门槛开始，随着获得更多数据，可以进行这种二分法评估之外的改进。
Background. Measuring the economic effectiveness of HIV-infection prevention activities poses special challenges in terms of behavioral change acid health outcomes assessment. Methods. One way to address this difficulty is to employ threshold analysis to determine a level of cost per HIV infection averted above which society would seem unwilling to pay. The authors employ a cost-utility analytic framework to determine a monetary threshold for HIV prevention programs, subject base-case results to sensitivity analyses, and apply these results to the Centers for Disease Control and Prevention's fiscal year 1993 budget for extramural HIV prevention programs. Results. The monetary threshold for cost per HIV infection averted was calculated to be $417,000 in 1993 dollars, and ranged from $185,000 to $648,000 depending upon the dollar amount society would be willing to pay per quality-adjusted life year gained. Conclusions. Economic evaluations of particular HIV-infection prevention activities at least can begin by determining whether their levels of effectiveness are above or below this derived monetary threshold, and refinements beyond this dichotomous evaluation can proceed as further data become available.