Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder
Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder
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DOI：
10.1016/j.neulet.2006.09.002
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发表时间：
2006-11-20
影响因子：
2.5
通讯作者：
Kennedy, James L.
中科院分区：
文献类型：
--
作者：
Ni, Xingqun;Bismil, Ramprasad;Kennedy, James L.
边缘型人格障碍（BPD）是一种慢性、致残和高危的精神障碍，其特征是在成年早期开始的情绪、人际关系、自我形象和冲动控制的调节中普遍存在不稳定模式。BPD影响约1%-2%的总人口，并且由于自杀和冲动行为而具有高死亡率。5-羟色胺2A受体基因（HTR 2A）被认为是BPD的候选基因，因为多条证据表明它在自杀，冲动和情感责任中起着重要作用。为了检测HTR 2A与BPD之间的关联，我们对111名患有BPD的白人患者和287名白人健康对照者的4种多态性rs6313（T102 C）、rs 4941573、rs 2296972和rs6314（His 452 Tyr）进行了基因分型。用UNPHASED程序比较病例组和对照组的等位基因和单倍型频率。基于等位基因、基因型或单体型分析，我们没有发现HTR 2A和BPD之间的显著关联。然而，在BPD患者中，HTR 2A与人格特质之间存在显著相关。rs6313的C等位基因和rs 4941573的A等位基因与较高的外向性评分相关。我们的研究结果表明，5-羟色胺2A受体基因可能不会发挥主要作用的边缘型人格障碍的病因，但可能有一个角色的人格特质。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Borderline personality disorder (BPD) is a chronic, disabling, and high-risk mental disorder characterized by a pervasive pattern of instability in regulation of emotion, interpersonal relationships, self-image, and impulse control beginning in early adulthood. BPD affects about]%-2% of the general population and has a high mortality rate as a result of suicide and impulsive behaviour. The serotonin 2A receptor gene (HTR2A) is considered a candidate gene for BPD because multiple lines of evidence suggest that it plays an important role in suicide, impulsivity and emotional liability. To test for an association between HTR2A and BPD, we genotyped four polymorphisms, rs6313 (T102C), rs4941573, rs2296972 and rs6314 (His452Tyr), in 111 Caucasian patients with BPD and 287 Caucasian healthy controls. The program UNPHASED was used to compare allele and haplotype frequencies between cases and controls. We did not find a significant association between HTR2A and BPD based on allele, genotype or haplotype analyses. However, there were significant associations between HTR2A and personality traits in the BPD patients. The C allele of rs6313 and the A allele of rs4941573 associated with a higher Extraversion score. Our results suggest that the serotonin 2A receptor gene may not play a major role in the aetiology of borderline personality disorder, but may have a role in personality traits. (c) 2006 Elsevier Ireland Ltd. All rights reserved.