Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
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DOI：
10.1016/j.neures.2006.07.012
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发表时间：
2006-11-01
影响因子：
2.9
通讯作者：
Takada, Masahiko
中科院分区：
文献类型：
--
作者：
Miyachi, Shigehiro;Lu, Xiaofeng;Takada, Masahiko
采用狂犬病病毒的逆行跨突触运输，我们调查了组织基底神经节输入后肢，近端和远端前肢，和orofacial表示的猕猴初级运动皮层（MI）。狂犬病注射到这些MI区域后4天，通过皮质-基底神经节环路在纹状体和丘脑底核（subthalamic nucleus，简称TH）中发生神经元标记。在纹状体中，观察到两组不同的标记：一组在背壳核中，另一组在腹侧纹状体（腹内侧壳核和腹侧核）中。背侧纹状体标记的somatotopically安排，其分布模式是在良好的符合皮质纹状体的输入，这样的后肢，orofacial，或前肢区位于背侧，腹侧，或中间区的壳核，分别。腹侧纹状体标记的分布模式在所有情况下基本相同。在海马，标记的神经元的躯体位置的安排是在注册与皮质丘脑底输入。目前的研究结果表明，皮质基底神经节运动电路涉及背壳核和延髓可能构成单独的闭环的躯体的基础上，而腹侧纹状体提供了共同的多突触投射到所有的身体部分表示在MI。(c)2006年Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
Employing retrograde transsynaptic transport of rabies virus, we investigated the organization of basal ganglia inputs to hindlimb, proximal and distal forelimb, and orofacial representations of the macaque primary motor cortex (MI). Four days after rabies injections into these MI regions, neuronal labeling occurred in the striatum and the subthalamic nucleus (STN) through the cortico-basal ganglia loop circuits. In the striatum, two distinct sets of the labeling were observed: one in the dorsal putamen, and the other in the ventral striatum (ventromedial putamen and nucleus accumbens). The dorsal striatal labeling was somatotopically arranged and its distribution pattern was in good accordance with that of the corticostriatal inputs, such that the hindlimb, orofacial, or forelimb area was located in the dorsal, ventral, or intermediate zone of the putamen, respectively. The distribution pattern of the ventral striatal labeling was essentially the same in all cases. In the STN, the somatotopic arrangement of labeled neurons was in register with that of corticosubthalamic inputs. The present results suggest that the cortico-basal ganglia motor circuits involving the dorsal putamen and the STN may constitute separate closed loops based on the somatotopy, while the ventral striatum provides common multisynaptic projections to all body-part representations in the MI. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.