Is the prevalence of wheeze in children altered by neonatal BCG vaccination?
Is the prevalence of wheeze in children altered by neonatal BCG vaccination?
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DOI：
10.1016/j.jaci.2006.12.672
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发表时间：
2007-05-01
影响因子：
14.2
通讯作者：
Niven, Robert M.
中科院分区：
文献类型：
--
作者：
Linehan, Mary F.;Frank, Timothy L.;Niven, Robert M.
Background: The prevalence of asthma and atopic disease has increased in recent decades, but precise reasons for this increase are unknown. BCG vaccination is thought to be among a group of vaccines capable of manipulating the immune system toward T(H)1 dominance and therefore reducing the likelihood of atopic disease.Objective: The aim of this study was to determine the influence of neonatal BCG vaccination on the prevalence of wheeze in a large community population of children. Method: In a historical cohort study, a parent-completed questionnaire was used to identify the prevalence of wheeze in BCG-vaccinated and nonvaccinated children in Manchester, England.Results: There were 2414 participants aged between 6 and 11 years. In a univariate analysis neonatal BCG vaccination was associated with a significantly lower prevalence of wheeze (odds ratio, 0.69; 95% CI, 0.55-0.86), and statistical significance was retained when the analysis was adjusted for potential confounders (odds ratio, 0.68; 95% CI, 0.53-0.87).Conclusion: These results demonstrate an association between asthma symptom prevalence and neonatal BCG vaccination, relating to a possible 27% reduction in prevalence, and are therefore of considerable public health importance.Clinical implications: The capacity of neonatal BCG vaccination to reduce the prevalence of respiratory symptoms in children warrants further investigation.
