Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells.
Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells.
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骨髓是心脏驻留干细胞的储存库。
DOI：
10.1038/srep28739
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发表时间：
2016-06-27
影响因子：
4.6
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Liu N;Qi X;Han Z;Liang L;Kong D;Han Z;Zhao S;He ZX;Li Z
驻留的心脏干细胞（CSCs）代表了成人心肌内的响应性干细胞库，并在心肌稳态和损伤中具有重要功能。然而，CSC的分布、起源、归巢和可能的治疗益处仍在讨论中。在这里，我们研究了骨髓（BM）干细胞是否有助于在心脏中重建CSC库。骨髓移植（BM transplantation，BMT）后骨髓细胞在心脏内的植入量较低，缺血再灌注（ischemia/reperfusion，I/R）可增加骨髓细胞的植入量，但不显著。我们阐明了超过50%的CSC来源于BM，并证实BM来源的CSC具有与宿主CSC相似的特征。此外，我们将骨髓来源的CSCs移植到心脏缺血模型中，并首次证明骨髓来源的CSCs可以在体内分化为心肌细胞。总之，骨髓干细胞可能是一个潜在的后备来源的CSC损伤后恢复心脏功能或维持稳态的CSC。
Resident cardiac stem cells (CSCs) represent a responsive stem cell reservoir within the adult myocardium and have a significant function in myocardial homeostasis and injury. However, the distribution, origin, homing and possible therapeutic benefits of CSCs are still under discussion. Here we investigated whether bone marrow (BM) stem cells could contribute to repopulating the pool of CSCs in heart. The engraftment of BM cells in heart was detected at a low level after BM transplantation (BMT) and ischemia/reperfusion (I/R) could increase BM cells engraftment but not significant. We clarified that more than 50% CSCs are derived from BM and confirmed that BM-derived CSCs have similar characteristics with the host CSCs. Furthermore, we transplanted BM-derived CSCs into heart ischemia models and presented evidence for the first time that BM-derived CSCs can differentiate into cardiomyocytes in vivo. In conclusions, BM stem cells could be a potential back-up source of CSCs for restoring heart function after injury or maintaining homeostasis of CSCs.
影响因子：
11.1
作者：
Palacios, Jose A.;Schneider, Michael D.
通讯作者：
Schneider, Michael D.