Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia
Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia
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两种多胺抗代谢物的协同作用可导致儿童白血病的快速治疗反应
DOI：
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发表时间：
1981
影响因子：
6.4
通讯作者：
J. Jänne
中科院分区：
文献类型：
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作者：
M. Siimes;P. Seppänen;L. Alhonen;J. Jänne
α-二氟甲基鸟氨酸和甲基乙二醛双（鸟苷酰腙），天然多胺生物合成的两种不同作用的抑制剂，顺序给药，产生了快速和独特的治疗反应，在4名儿童晚期淋巴细胞和髓细胞白血病。两种化合物作用之间的协同作用是基于独特的药物相互作用;先前使用二氟甲基鸟氨酸进行的治疗大大增加了随后给予的甲基乙二醛双（鸟苷酰腙）的摄取，这一点通过循环白血病细胞中后一种药物的实际测定得到了验证。与联合药物方案相关的副作用要么不存在，要么轻微。
Sequential administration of α‐difluoromethyl ornithine and methylglyoxal bis(guanylhydrazone), two differently acting inhibitors of the biosynthesis of natural polyamines, produced a rapid and distinct therapeutic response in four children with advanced lymphoblastic and in one with myeloblastic leukemia. The synergism between the action of the two compounds was based upon a unique drug interaction; a preceding treatment with difluoromethyl ornithine greatly increased the uptake of subsequently administered methylglyoxal bis‐(guanylhydrazone) as verified by the actual determinations of the latter drug in the circulating leukemia cells. The side‐effects associated with the combined drug regimen were either absent or mild.