Improved thickness measurement method for choroidal hyperpermeability in central serous chorioretinopathy
Improved thickness measurement method for choroidal hyperpermeability in central serous chorioretinopathy
复制标题
中心性浆液性脉络膜视网膜病变患者脉络膜通透性增高的厚度测量方法的改进
DOI：
10.18240/ijo.2020.09.10
复制
发表时间：
2020-09-18
影响因子：
1.4
通讯作者：
Cai, Shan-Jun
中科院分区：
文献类型：
--
作者：
Chen, Xing-Wang;Han, Fang-Yuan;Cai, Shan-Jun
目的：利用吲哚菁绿血管造影（ICGA）联合光学相干断层扫描（OCT）观察中心性浆液性脉络膜视网膜病变（CSC）患者光动力疗法（PDT）后脉络膜高通透性区域（CHA）的脉络膜厚度变化。
方法：这是一项针对17例（17只眼）CSC患者的队列研究。所有患者均通过ICGA确定CHA范围。根据CHA是否累及黄斑中心凹将患者分为两组，累及黄斑中心凹的为A组，未累及的为B组。所有患者均针对ICGA显示的CHA区域接受半剂量维替泊芬PDT治疗。在治疗前、治疗后1个月及3个月时采用OCT测量脉络膜厚度，每次测量均获取黄斑中心凹及CHA区域的脉络膜厚度值。次要观察指标为最佳矫正视力（BCVA）及视网膜下液（SRF）量的变化。
结果：A组及所有患者在PDT治疗前、治疗后1个月及3个月时的中心脉络膜厚度差异均有统计学意义（均P （此处原文P值后内容缺失 ）
AIM: To observe choroidal thickness changes in the choroidal hyperpermeability area (CHA) in patients with central serous chorioretinopathy (CSC) after photodynamic therapy (PDT) using indocyanine green angiography (ICGA) combined with optical coherence tomography (OCT).METHODS: This was a cohort study of 17 eyes (17 patients) with CSC. In all patients, the range of CHA was determined by ICGA. The patients were divided into two groups based on CHA covered the fovea (group A) or not (group B). All patients received half-dose verteporfin PDT over CHA in ICGA. Choroidal thickness was measured by OCT before, 1, and 3mo after treatment. The choroidal thickness values of the fovea and CHAs were obtained for each measurement. Secondary outcomes were changes in the best-corrected visual acuity (BCVA) and amount of subretinal fluid (SRF).RESULTS: The differences in center choroidal thickness at baseline and at 1 and 3mo post-PDT were statistically significant in group A and all patients (both P