Degeneration of cortical function in the Royal College of Surgeons rat
Degeneration of cortical function in the Royal College of Surgeons rat
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DOI：
10.1016/j.visres.2011.08.012
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发表时间：
2011-10-15
期刊：
影响因子：
1.8
通讯作者：
Coffey, Peter J.
中科院分区：
文献类型：
--
作者：
Gias, Carlos;Vugler, Anthony;Coffey, Peter J.
本研究的目的是确定皇家外科医师学会(RCS)大鼠皮质功能退行性变的进展。通过使用不同空间频率的光栅对本征信号进行光学成像来测量皮质反应。随后，也对广谱光脉冲进行了跨大脑皮层的电生理记录。我们发现，早在4周龄时，视觉信息的皮质处理就出现了显著的退化。这些结果表明，RCS大鼠皮质反应的退化在发育正常完成之前就开始了。(C)2011爱思唯尔有限公司。保留所有权利。
The purpose of the current study was to determine the progress of cortical functional degeneration in the Royal College of Surgeons (RCS) rat. Cortical responses were measured with optical imaging of intrinsic signals using gratings of various spatial frequencies. Subsequently, electrophysiological recordings were also taken across cortical layers in response to a pulse of broad-spectrum light. We found significant degeneration in the cortical processing of visual information as early as 4 weeks of age. These results show that degeneration in the cortical response of the RCS rat starts before development has been properly completed. (C) 2011 Elsevier Ltd. All rights reserved.