Dorsal spinocerebellar tract neurons respond to contralateral limb stepping
Dorsal spinocerebellar tract neurons respond to contralateral limb stepping
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DOI：
10.1007/s00221-003-1378-8
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发表时间：
2003-04-01
影响因子：
2
通讯作者：
Eian, J
中科院分区：
文献类型：
--
作者：
Poppele, RE;Rankin, A;Eian, J
脊髓小脑束携带的本体感觉信息为脊髓小脑提供了主要的输入，它在协调姿势和运动的运动输出方面起着重要作用。直到最近，人们一直认为脊髓小脑束(DSCT)背侧传递的信息被组织成代表同侧后肢的单个肌肉或单个关节。然而，最近的研究表明，DSCT的活动代表了后肢的整体运动学参数。我们现在提出的证据表明，DSCT神经元也受到任一后肢被动步态运动的调制，这意味着它们接受双侧感觉输入。在被研究的78个细胞中，大约三分之二的细胞对对侧肢体的单独运动有显着的反应，大约70%的细胞对两足动物的运动的反应与对同侧的单独运动的反应不同。在麻醉、瘫痪的猫和未麻醉的去大脑的猫中观察到了相同的基本行为，尽管去大脑的猫平均可能有更大的反应。结果表明，许多DSCT细胞可能编码有关肢体间协调的信息。
Proprioceptive sensory information carried by spinocerebellar tracts provides a major input to the spinocerebellum, which has an important role in coordinating motor output for posture and locomotion. Until recently it was assumed that the information transmitted by the dorsal spinocerebellar tract (DSCT) was organized to represent single muscles or single joints in the ipsilateral hindlimb. Recent studies have shown, however, that DSCT activity represents global kinematic parameters of the hindlimb. We now present evidence that the DSCT neurons are also modulated by passive step-like movements of either hindlimb, implying they receive a bilateral sensory input. About two-thirds of 78 cells studied had significant responses to movements of the contralateral limb alone and about 70% responded differently to bipedal movements than to ipsilateral movement alone. The same basic behavior was observed in anesthetized, paralyzed cats and in unanesthetized, decerebrate cats, although decerebrate cats may have had larger responses on average. The results suggest that many DSCT cells may encode information about interlimb coordination.