Coactivator recruitment: a new role for PAS domains in transcriptional regulation by the bHLH-PAS family.
Coactivator recruitment: a new role for PAS domains in transcriptional regulation by the bHLH-PAS family.
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DOI：
10.1002/jcp.22067
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发表时间：
2010-06
影响因子：
5.6
通讯作者：
Gardner, Kevin H.
中科院分区：
文献类型：
--
作者：
Partch, Carrie L.;Gardner, Kevin H.
转录调控依赖于转录因子和共激活因子之间的相互作用层，控制特异性，时间调节和转录程序执行的程度。转录调控领域的一个关键问题是确定转录因子和辅激活因子构建分级蛋白质组装体的结构机制。bHLH-PAS（basic helix-loop-helix Per-ARNT-Sim domain）转录调节因子家族由转录因子和共激活因子组成，尽管结构保守，但它们具有不同的功能。在该家族中，串联PAS结构域通常介导转录因子的二聚化，而C-末端反式激活结构域促进转录因子和共激活因子之间的动态相互作用。然而，最近的研究表明，模块化PAS结构域在调节辅激活因子募集和寡聚化状态方面发挥着重要作用。在这里，我们提供了一个简要的概述的结构和功能的研究，已经确定了一个新的蛋白质相互作用的界面上PAS结构域利用的转录因子和辅激活因子内的bHLH-PAS家族。
Transcriptional regulation is dependent on layers of interactions between transcription factors and coactivators, controlling the specificity, temporal regulation, and extent to which transcriptional programs are executed. A key issue in the field of transcriptional regulation is to identify structural mechanisms by which transcription factors and coactivators build hierarchical protein assemblies. The bHLH-PAS (basic helix-loop-helix Per-ARNT-Sim domain) family of transcriptional regulators is comprised of both transcription factors and coactivators, which have different functions despite conserved domain architecture. Within this family, the tandem PAS domains typically mediate dimerization of the transcription factors, while C-terminal transactivation domains facilitate the dynamic interplay between transcription factors and coactivators. However, recent studies have shown that the modular PAS domains play an important role in regulating coactivator recruitment and oligomerization status. Here we provide a brief overview of the structural and functional studies that have identified a novel protein interaction interface on PAS domains utilized by both transcription factors and coactivators within the bHLH-PAS family.
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