Aberrant localization of β-catenin correlates with overexpression of its target gene in human papillary thyroid cancer
Aberrant localization of β-catenin correlates with overexpression of its target gene in human papillary thyroid cancer
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DOI：
10.1210/jc.87.7.3433
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发表时间：
2002-07-01
影响因子：
5.8
通讯作者：
Kanematsu, T
中科院分区：
文献类型：
--
作者：
Ishigaki, K;Namba, H;Kanematsu, T
已知Wnt/β-连环蛋白信号通路的改变发生在组分基因如APC、Axin和β-连环蛋白的突变中，并且在肿瘤发生中起致病作用。激活的Wnt信号稳定β-连环蛋白，其与T细胞因子相关，导致下游靶基因包括c-myc和细胞周期蛋白D1的反式激活。为了探讨Wnt/β-catenin信号通路在甲状腺肿瘤发生中的作用，我们分析了5种人甲状腺癌细胞系和132例甲状腺肿瘤组织样本中Wnt/β-catenin信号通路的激活和定位。在所有细胞系中均观察到β-连环蛋白的移位。在四种甲状腺癌细胞系中的两种中观察到T细胞因子的组成性激活，
Alterations of the Wnt/beta-catenin signaling pathway are known to occur in mutations of the component genes such as APC, Axin, and beta-catenin, and play a pathogenetic role in tumorigenesis. Activated Wnt signaling stabilizes beta-catenin, which associates with T cell factor, resulting in transactivation of the downstream target genes including c-myc and cyclin D1. To investigate the involvement of Wnt/beta-catenin signaling pathway in thyroid tumorigenesis, we analyzed its activation and localization in 5 human thyroid cancer cell lines and 132 thyroid tumor tissue samples. Dislocalization of beta-catenin was observed in all cell lines. Constitutive activation of T cell factor in two of four thyroid cancer cell lines was observed using