DISTRIBUTION OF PUTATIVE ODOR RECEPTOR PROTEINS IN OLFACTORY EPITHELIUM
DISTRIBUTION OF PUTATIVE ODOR RECEPTOR PROTEINS IN OLFACTORY EPITHELIUM
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DOI：
10.1097/00001756-199206000-00017
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发表时间：
1992-06-01
期刊：
影响因子：
1.7
通讯作者：
MORI, K
中科院分区：
文献类型：
--
作者：
KOSHIMOTO, H;KATOH, K;MORI, K
要调查化学的空间定位的推定的气味受体蛋白，我们合成了一种多肽，其对应于一个区域的推定的气味受体蛋白，I3，并提出了一种抗体的肽。在大鼠嗅上皮中，抗体特异性地识别嗅觉受体神经元的一个小子集的纤毛，这表明气味受体蛋白选择性地定位在纤毛中。嗅觉受体神经元具有免疫反应纤毛分布稀疏整个上皮。这表明，受体神经元表达类似的气味受体蛋白可能分布在上皮相似。
To investigate immunohistochemically the spatial localization of putative odour receptor proteins, we synthesized a polypeptide which corresponds to a region of a putative odour receptor protein, I3, and raised an antibody to the peptide. In rat olfactory epithelium, the antibody specifically recognized cilia of a small subset of olfactory receptor neurons, suggesting that the odour receptor protein is localized selectively in the cilia. Olfactory receptor neurons having immunoreactive cilia were distributed sparsely throughout the epithelium. This suggests that receptor neurons expressing a similar odour receptor protein are probably distributed similarly in the epithelium.