CHITOSAN - A NEW HEMOSTATIC
CHITOSAN - A NEW HEMOSTATIC
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DOI：
10.1016/s0003-4975(10)60649-2
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发表时间：
1983-01-01
影响因子：
4.6
通讯作者：
RAINER, WG
中科院分区：
文献类型：
--
作者：
MALETTE, WG;QUIGLEY, HJ;RAINER, WG
壳聚糖是节肢动物甲壳素的脱乙酰基衍生物。它与去纤化的血液、肝素化的血液和洗净的红细胞接触形成凝结物。当针织DeBakey移植物用壳聚糖处理时，它们是不透血的。在24小时检查这些移植物，发现没有再出血。检查时间分别为1、2、3、4mo。在狗身上，移植物被包裹在光滑的肌肉中，有活的内皮衬里和丰富的血管。对照移植物显示出通常的纤维性愈合。
Chitosan is a deacetylated derivative of arthropod chitin. It formed a coagulum in contact with defibrinated blood, heparinized blood and washed red cells. when knitted DeBakey grafts were treated with chitosan, they were impermeable to blood. Examination of these grafts at 24 h revealed no rebleeding. Examination at 1, 2, 3 and 4 mo. showed the grafts to be encased in smooth muscle with a living endothelial lining and an abundant vasa vasorum in dogs. Control grafts showed the usual fibrous healing.