Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women
Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women
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DOI：
10.1038/sj.ejcn.1601622
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发表时间：
2003-08-01
影响因子：
4.7
通讯作者：
Germain, A
中科院分区：
文献类型：
--
作者：
Cuevas, AM;Irribarra, VL;Germain, A
背景：耳鸣和高胆固醇血症与内皮功能障碍有关，内皮功能障碍是动脉粥样硬化的一种致病事件。大豆蛋白可降低血浆胆固醇，但其对内皮功能的影响信息很少。目的：评价分离大豆蛋白与酪蛋白酸盐相比对绝经后高胆固醇血症妇女血浆脂蛋白和内皮功能的影响。设计：随机、双盲、交叉试验。设置：智利天主教大学门诊。受试者：招募了18名健康的绝经后高胆固醇血症女性，包括并完成了该方案。在试验期间，所有患者遵循低脂肪/低胆固醇饮食，并被随机分配接受分离的大豆蛋白或匹配的酪蛋白酸盐4周，然后是替代治疗，直到第8周。在研究前和结束时的第一和第二阶段，血浆脂蛋白水平和内皮功能（流量介导的扩张（FMD）的肱动脉）进行了evaluated.Results：血浆总和低密度脂蛋白（LDL）-胆固醇浓度显着降低与低脂肪/低胆固醇饮食相比，研究前，无论是酪蛋白或大豆蛋白。酪蛋白酸盐或大豆蛋白干预之间的血浆脂质浓度没有显着差异。FMD不随酪蛋白酸盐的变化而变化。相比之下，当给予大豆蛋白时，FMD与研究前相比显著升高（9.4 +/- 1.8% vs 5.3 +/- 1.2%; P < 0.05），与酪蛋白酸盐干预相比（9.4 +/- 1.8% vs 4.9 +/- 1.5%; P < 0.033）。这些结果表明，在绝经后高胆固醇血症的妇女，大豆蛋白改善内皮功能，无论血浆脂蛋白的变化。
Background: Postmenopausia and hypercholesterolemia are related to endothelial dysfunction, a pathogenic event in atherosclerosis. Soy protein reduces plasma cholesterol, but there is scanty information about its effect on endothelial function.Objective: To evaluate the effect of isolated soy protein compared to caseinate on plasma lipoproteins and endothelial function in postmenopausal hypercholesterolemic women.Design: Randomized, double-blind, cross-over trial.Setting: Outpatient clinic of the Catholic University of Chile.Subjects: Eighteen healthy, postmenopausal women with hypercholesterolemia were recruited, included and completed the protocol.Interventions: During the trial, all patients followed a low fat/low cholesterol diet and were randomly assigned to receive isolated soy protein or matching caseinate for 4 weeks, and then the alternative treatment until week 8. At pre-study and at the end of the first and second period, plasma lipoprotein levels and endothelial function (flow-mediated dilatation (FMD) of the brachial artery) were evaluated.Results: Plasma total and low density lipoprotein (LDL)-cholesterol concentration were significantly lower with the low fat/low cholesterol diet compared to pre-study, either with caseinate or soy protein. No significant differences in plasma lipid concentration between caseinate or soy protein interventions were observed. FMD did not change with the caseinate. In contrast, when soy protein was administered, FMD was significantly higher compared to pre-study (9.4 +/- 1.8% vs 5.3 +/- 1.2%; P < 0.05) and compared to caseinate intervention (9.4 +/- 1.8% vs 4.9 +/- 1.5%; P < 0.033).Conclusions: These results suggest that in postmenopausal hypercholesterolemic women, soy protein improves endothelial function, regardless of changes in plasma lipoproteins.