Hippuric acid as a major excretion product associated with black tea consumption
Hippuric acid as a major excretion product associated with black tea consumption
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DOI：
10.1080/004982500237703
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发表时间：
2000-03-01
期刊：
影响因子：
1.8
通讯作者：
Mitchell, LA
中科院分区：
文献类型：
--
作者：
Clifford, MN;Copeland, EL;Mitchell, LA
1.招募了9名习惯喝茶的志愿者，要求他们遵循低多酚和低咖啡因饮食6天，并提供每日24小时尿液样本。在实验的第一天，在标准化条件下冲泡的浓红茶被重新引入到志愿者的饮食中。尿液样本的H-1-NMR和HPLC分析表明，红茶（每天6-10杯）的消费与马尿酸排泄量相对于对照组显著增加（p = 0.00017）相关，从153-512增加到742-1374 mg/天（-1）。大量马尿酸的排泄以前与红茶消费无关。3，对于一些志愿者。处理的苯甲酸量超过每日允许摄入量（ADI），但认为这不构成任何危害。II质量平衡分析表明，即使获得100%的转化，也不能从红茶中的没食子酸、黄烷醇、黄酮醇糖苷和茶黄素的含量中获得必需量的苯甲酸，这表明茶红素（红茶的主要且化学上不明确的多酚）可能是重要来源。
1. Nine habitual tea-drinking volunteers were recruited and asked to follow a low-polyphenol and low-caffeine diet for 6 days and to provide daily 24-h urine samples. On day 1 of the experiment strong black tea brewed under standardized conditions was reintroduced to the volunteers' diet.2. H-1-NMR and HPLC profiling of the urine samples indicated that consumption of black tea (6-10 mugs per day) was associated with a significant (p = 0.00017) increase in hippuric acid excretion relative to control, increasing from 153-512 to 742-1374 mg day(-1). The excretion of substantial amounts of hippuric acid has nor previously been associated with black tea consumption.3, For some volunteers. the quantity of benzoic acid processed exceeded the acceptable daily intake (ADI), but this is not considered to constitute any hazard.4. ii mass-balance analysis indicated that the necessary quantity of benzoic acid could not be obtained from the: contents of gallic acid, flavanols, flavonol glycosides and theaflavins in black tea even if 100% transformation was obtained, suggesting that the thearubigins (the major and chemically ill-defined polyphenols of black tea) may be an important source.