Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction.
Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction.
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DOI：
10.1177/1073858415579405
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Dong Y
中科院分区：
文献类型：
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作者：
Huang YH;Schlüter OM;Dong Y
在接触可卡因后，伏隔核 (NAc) 中发现“沉默突触”水平出现短暂但显着的增加，“沉默突触”是未成熟谷氨酸能突触的特征，仅包含 NMDA 受体，而没有稳定表达的 AMPA 受体。由于 NAc 是与成瘾相关行为的形成有关的关键前脑区域，最初的发现引发了人们对这些药物诱导的突触是否以及如何成熟并可能导致成瘾相关行为的猜测。在这里，我们总结了在认识沉默突触成熟的通路特异性调控及其对行为的多种影响方面的最新进展。我们提供了指导假设的更新——“神经复兴假说”——以及最近出现的可卡因渴望和复发中沉默突触的证据。
A transient but prominent increase in the level of “silent synapses”—a signature of immature glutamatergic synapses that contain only NMDA receptors without stably expressed AMPA receptors—has been identified in the nucleus accumbens (NAc) following exposure to cocaine. As the NAc is a critical forebrain region implicated in forming addiction-associated behaviors, the initial discoveries have raised speculations about whether and how these drug-induced synapses mature and potentially contribute to addiction-related behaviors. Here, we summarize recent progress in recognizing the pathway-specific regulations of silent synapse maturation, and its diverse impacts on behavior. We provide an update of the guiding hypothesis—the “neural rejuvenation hypothesis”—with recently emerged evidence of silent synapses in cocaine craving and relapse.