Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study
Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study
复制标题
DOI：
10.1111/j.1538-7836.2006.02237.x
复制
发表时间：
2006-12-01
影响因子：
10.4
通讯作者：
Folsom, A. R.
中科院分区：
文献类型：
--
作者：
Lutsey, P. L.;Cushman, M.;Folsom, A. R.
背景：止血因子和内皮标志物可能在心血管疾病（CVD）发病率的种族/民族差异中发挥一定作用。然而，关于止血因子和内皮标志物在种族/民族群体中的信息很少。目的：描述四个美国种族/民族群体（高加索人、黑人、西班牙人和中国人）中选定的止血因子和内皮标志物的平均水平。患者和方法：采用多民族动脉粥样硬化研究基线数据（参与者年龄：45-84岁）。使用协方差模型的性别分析和两两比较的t检验来比较因素和标记的均值。对人口统计学和传统心血管疾病危险因素进行了调整。差异有统计学意义，P < 0.05。结果：黑人的VIII因子、d -二聚体、纤溶酶抗纤溶酶（PAP）和血管性血友病因子水平最高，纤维蛋白原和e -选择素水平最高（仅限女性），但细胞间粘附分子1 （ICAM-1）水平最低，而男性的纤溶酶原激活物抑制剂-1 （PAI-1）水平最低。白人和西班牙裔倾向于有中等水平的因子和标志物，尽管他们有最高水平的ICAM-1，西班牙裔有最高的平均水平的纤维蛋白原和e -选择素（仅限女性）。中国参与者的PAI-1水平是最高的，但在所有其他因素和标记中是最低的，或者是最低的。未观察到可溶性血栓调节蛋白差异。结论：在这个大型队列中，止血因子和内皮标志物的平均水平因种族/民族而异，即使在调整了传统的心血管疾病危险因素后也是如此。
Background: Hemostatic factors and endothelial markers may play some role in racial/ethnic differences in cardiovascular disease (CVD) rates. However, little information exists on hemostatic factors and endothelial markers across racial/ethnic groups. Objectives: To describe, in four American racial/ethnic groups (Caucasian, Black, Hispanic, and Chinese), mean levels of selected hemostatic factors and endothelial markers. Patients and methods: Multi-ethnic Study of Atherosclerosis baseline data were used (participant age: 45-84 years). Sex-specific analysis of covariance models, and t-tests for pairwise comparisons, were used to compare means of factors and markers. Adjustments were made for demographics and traditional CVD risk factors. Differences were significant at P < 0.05. Results: Blacks had the highest levels of factor VIII, D-Dimer, plasmin-antiplasmin (PAP), and von Willebrand factor, among the highest levels of fibrinogen and E-selectin (women only), but among the lowest levels of intercellular adhesion molecule 1 (ICAM-1), and, in men, the lowest levels of plasminogen activator inhibitor-1 (PAI-1). Whites and Hispanics tended to have intermediate levels of factors and markers, although they had the highest levels of ICAM-1, and Hispanics had the highest mean levels of fibrinogen and E-selectin (women only). Chinese participants had among the highest levels of PAI-1, but the lowest, or among the lowest, of all other factors and markers. No soluble thrombomodulin differences were observed. Conclusions: In this large cohort, hemostatic factor and endothelial marker mean levels varied by race/ethnicity, even after adjustment for traditional CVD risk factors.