Mechanisms of spike inhibition in a cortical network induced by transcranial magnetic stimulation
Mechanisms of spike inhibition in a cortical network induced by transcranial magnetic stimulation
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DOI：
10.1016/j.neucom.2004.11.002
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发表时间：
2005-06
期刊：
影响因子：
6
通讯作者：
Y. Miyawaki;M. Okada
中科院分区：
文献类型：
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作者：
Y. Miyawaki;M. Okada
我们提出了经颅磁刺激(TMS)引起神经干扰的机制。TMS作为一种强大而独特的无创刺激人脑的实验工具被广泛应用，但其对大脑皮质功能有明显的抑制作用。然而，TMS诱导抑制的基本机制仍不清楚。在这篇文章中，我们通过计算证明，在一个基于电导的网络模型中，TMS在没有离子通道的情况下诱导了持续的棘波抑制，这表明TMS并不一定抑制每个神经元；相反，皮层网络中兴奋性和抑制性输入平衡的崩溃是TMS诱导抑制的关键。
We propose mechanisms of neural interference induced by transcranial magnetic stimulation (TMS). TMS is widely used as a powerful and unique experimental tool to stimulate the human brain noninvasively, which typically induces inhibitory effect on the cortical functions. However, the fundamental mechanism of TMS-induced suppression is still unclear. In this paper, we computationally demonstrate that TMS induces sustained spike inhibition in a conductance-based network model without the ion channel which is necessary for spike inhibition in an isolated single neuron, suggesting that each individual neuron is not necessarily suppressed by TMS; rather, a collapse of excitatory and inhibitory input balance in the cortical network is crucial for TMS-induced suppression.