The plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells.
The plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells.
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DOI：
10.1155/2012/121424
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发表时间：
2012
影响因子：
--
通讯作者：
Hernández JA
中科院分区：
文献类型：
--
作者：
Chifflet S;Hernández JA
极化上皮表型的建立和维持需要细胞骨架成分的特征性组织。有许多细胞效应物参与调节上皮细胞的细胞骨架。最近，质膜电位（PMP）的修改已被建议参与上皮细胞骨架组织的调制。在这里，我们回顾了证据，表明不同上皮细胞的PMP变化促进了细胞骨架组织的特征性修饰，重点是肌动蛋白细胞骨架。介导这些效应的分子途径可能包括电压敏感性整合膜蛋白和/或对表面电位敏感的外周蛋白。细胞骨架组织的电压依赖性似乎在几个生理过程中有影响，包括上皮伤口愈合和细胞凋亡。
The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential (PMP) have been suggested to participate in the modulation of the cytoskeletal organization of epithelia. Here, we review evidence showing that changes in the PMP of diverse epithelial cells promote characteristic modifications in the cytoskeletal organization, with a focus on the actin cytoskeleton. The molecular paths mediating these effects may include voltage-sensitive integral membrane proteins and/or peripheral proteins sensitive to surface potentials. The voltage dependence of the cytoskeletal organization seems to have implications in several physiological processes, including epithelial wound healing and apoptosis.