Neural Androgen Receptors Modulate Gene Expression and Social Recognition But Not Social Investigation.
Neural Androgen Receptors Modulate Gene Expression and Social Recognition But Not Social Investigation.
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DOI：
10.3389/fnbeh.2016.00041
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发表时间：
2016
影响因子：
3
通讯作者：
Westberg L
中科院分区：
文献类型：
--
作者：
Karlsson SA;Studer E;Kettunen P;Westberg L
性别和雄激素受体（AR）对社会偏好和社会记忆的作用是相当未知的。在这项小鼠研究中，我们比较了雄性，雌性和雄性缺乏AR的神经系统，ARNesDel，在社会偏好方面，评估与三腔装置测试，和社会识别，评估与社会歧视程序。在社会歧视测试中，我们还评估了刺激动物性别的初步重要性。新的物体识别和嗅觉进行了研究，以补充社会测试的结果。基因表达分析揭示了参与性别和雄激素对社会行为影响的分子。所有三个测试组在三腔装置测试中都表现出社会偏好。在这两个社会测试中，AR独立的性二态性被认为是在女性同种的社会调查的持久性，而对男性刺激小鼠的社会利益是相似的，在所有组。男性和女性控制识别同种独立于他们的性别，而ARNesDel男性承认女性，但不是男性刺激小鼠。此外，非社会行为不受AR缺陷的影响。下丘脑和杏仁核的基因表达分析表明，Oxtr，Cd38，Esr1，Cyp19a1，Ucn3，Crh和Gtf2i在三组之间差异表达。总之，我们的研究结果表明，AR是需要识别的男性，而不是女性同种，而被视为社会调查对两性。此外，AR似乎调节与催产素、雌激素和威廉综合征相关的基因。
The role of sex and androgen receptors (ARs) for social preference and social memory is rather unknown. In this study of mice we compared males, females and males lacking ARs specifically in the nervous system, ARNesDel, with respect to social preference, assessed with the three-chambered apparatus test, and social recognition, assessed with the social discrimination procedure. In the social discrimination test we also evaluated the tentative importance of the sex of the stimulus animal. Novel object recognition and olfaction were investigated to complement the results from the social tests. Gene expression analysis was performed to reveal molecules involved in the effects of sex and androgens on social behaviors. All three test groups showed social preference in the three-chambered apparatus test. In both social tests an AR-independent sexual dimorphism was seen in the persistence of social investigation of female conspecifics, whereas the social interest toward male stimuli mice was similar in all groups. Male and female controls recognized conspecifics independent of their sex, whereas ARNesDel males recognized female but not male stimuli mice. Moreover, the non-social behaviors were not affected by AR deficiency. The gene expression analyses of hypothalamus and amygdala indicated that Oxtr, Cd38, Esr1, Cyp19a1, Ucn3, Crh, and Gtf2i were differentially expressed between the three groups. In conclusion, our results suggest that ARs are required for recognition of male but not female conspecifics, while being dispensable for social investigation toward both sexes. In addition, the AR seems to regulate genes related to oxytocin, estrogen and William’s syndrome.