Epithelial-mesenchymal transition and its transcription factors.
Epithelial-mesenchymal transition and its transcription factors.
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DOI：
10.1042/bsr20211754
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发表时间：
2022-01-28
影响因子：
4
通讯作者：
Palchaudhuri S
中科院分区：
文献类型：
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作者：
Debnath P;Huirem RS;Dutta P;Palchaudhuri S
上皮-间充质转化或EMT是一个非常动态的过程，涉及上皮细胞向间充质细胞的转化，由一系列信号传导途径刺激，导致细胞形态的变化，上皮特征的抑制和特性的获得，例如增强的细胞运动性和侵袭性，减少细胞凋亡引起的细胞死亡，对化疗药物的抗性等。EMT在胚胎发育、组织纤维化、伤口愈合以及肿瘤转移过程中起着重要作用。多年来，各个实验室的工作已经确定了大量转录因子（TF），包括EMT的主调节因子，具有直接调节EMT过程的能力。在这篇综述中，我们将这些EMT TF放在一起，并讨论了它们在这一过程中的作用。我们还试图关注它们的作用机制、相互依赖性以及它们形成的大型监管网络。随后，已经清楚的是，EMT背后的转录调控网络的组成和结构可能基于各种生理和病理背景而变化，甚至以细胞/组织类型依赖的方式变化。
Epithelial–mesenchymal transition or EMT is an extremely dynamic process involved in conversion of epithelial cells into mesenchymal cells, stimulated by an ensemble of signaling pathways, leading to change in cellular morphology, suppression of epithelial characters and acquisition of properties such as enhanced cell motility and invasiveness, reduced cell death by apoptosis, resistance to chemotherapeutic drugs etc. Significantly, EMT has been found to play a crucial role during embryonic development, tissue fibrosis and would healing, as well as during cancer metastasis. Over the years, work from various laboratories have identified a rather large number of transcription factors (TFs) including the master regulators of EMT, with the ability to regulate the EMT process directly. In this review, we put together these EMT TFs and discussed their role in the process. We have also tried to focus on their mechanism of action, their interdependency, and the large regulatory network they form. Subsequently, it has become clear that the composition and structure of the transcriptional regulatory network behind EMT probably varies based upon various physiological and pathological contexts, or even in a cell/tissue type-dependent manner.
Kruppel 样因子 4 对肝细胞癌细胞上皮间质转化的抑制。
影响因子：
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作者：
Li Q;Song W;Wang W;Yao S;Tian C;Cai X;Wang L
通讯作者：
Wang L
T-box 转录因子 Brachyury 通过抑制 E-钙粘蛋白表达促进肾间质纤维化。
DOI：
10.1186/s12964-014-0076-4
发表时间：
2014-11-30
期刊：
Cell communication and signaling : CCS
影响因子：
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作者：
Sun S;Sun W;Xia L;Liu L;Du R;He L;Li R;Wang H;Huang C
通讯作者：
Huang C