Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy.
Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy.
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DOI：
10.3389/fcimb.2016.00058
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发表时间：
2016
影响因子：
5.7
通讯作者：
McBride JW
中科院分区：
文献类型：
--
作者：
Lina TT;Farris T;Luo T;Mitra S;Zhu B;McBride JW
查菲埃里希体是一种小型革兰氏阴性专性胞内细菌，优先感染单核吞噬细胞。它是人类嗜单核细胞埃立克体病（HME）的病原体，HME是一种新出现的威胁生命的蜱传人畜共患病。E. Chaffeensis建立细胞内感染，并避免宿主防御尚未得到很好的理解，但涉及与串联和锚蛋白重复效应蛋白相关的功能相关的宿主-病原体相互作用。在这篇综述中，我们讨论了最近的进展，我们了解的分子和细胞机制，埃里希体宿主细胞重编程策略，使细胞内生存。
Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis. Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. In this review, we discuss the recent advances in our understanding of the molecular and cellular mechanisms that underlie Ehrlichia host cellular reprogramming strategies that enable intracellular survival.