α1,3 Glucans Are Dispensable in Aspergillus fumigatus

α1,3 Glucans Are Dispensable in Aspergillus fumigatus
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DOI:
10.1128/ec.05270-11
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发表时间:
2012-01-01
期刊:
影响因子:
--
通讯作者:
Beauvais, Anne
Beauvais, Anne
中科院分区:
其他
文献类型:
--
作者:
Henry, Christine;Latge, Jean-Paul;Beauvais, Anne

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通过连续缺失三种α 1,3葡聚糖合酶基因(AGS 1、AGS 2和AGS 3)获得的烟曲霉的三重α 1,3葡聚糖合酶突变体具有缺乏α 1,3葡聚糖的细胞壁。α 1,3葡聚糖的缺乏既不影响分生孢子萌发也不影响菌丝体营养生长,并且通过β 1,3葡聚糖和/或几丁质含量的增加来补偿。
A triple alpha 1,3 glucan synthase mutant of Aspergillus fumigatus obtained by successive deletions of the three alpha 1,3 glucan synthase genes (AGS1, AGS2, and AGS3) has a cell wall devoid of alpha 1,3 glucans. The lack of alpha 1,3 glucans affects neither conidial germination nor mycelial vegetative growth and is compensated by an increase in beta 1,3 glucan and/or chitin content.