Free fatty acid composition of human and rat peripheral nerve.
Free fatty acid composition of human and rat peripheral nerve.
复制标题
人和大鼠周围神经的游离脂肪酸组成。
DOI：
10.1111/j.1471-4159.1981.tb01720.x
复制
发表时间：
1981
影响因子：
4.7
通讯作者：
Moyer,TP
中科院分区：
文献类型：
--
作者：
Yao,JK;Dyck,PJ;VanLoon,JA;Moyer,TP
周围神经的游离脂肪酸（FFA）组成与红细胞相似，但两者的组成不同于脑和其他组织。神经和红细胞中大约75%的FFA是饱和的，<5%是多不饱和的，而在脑和其他组织中，30 - 45%的FFA是饱和的，25 - 50%是多不饱和的。大约10 - 15%的神经总FFA具有非常长的链长[C24、C26、C28和C30]。神经内膜中这些极长链FFA的存在不能通过红细胞滞留或脂质降解来解释。在沃勒变性的显着增加18：1，饱和FFA的减少，被发现在大鼠坐骨神经内膜，但接近正常值时，纤维再生正在进行中。而链长≥ C26的FFA成分随神经的变性或修复而无明显变化。神经和脑FFA组成之间的这种显著差异的代谢意义尚不清楚，但可能反映了不同的功能特性。
The free fatty acid (FFA) composition of peripheral nerve resembles that of erythrocytes but the composition of both is different from that of brain and other tissues. Approximately 75% of FFAs of nerve and erythrocytes are saturated and <5% are polyunsaturated whereas in brain and other tissues, 30‐45% of FFAs are saturated and 25‐50% are polyunsaturated. Approximately 10‐15% of the total FFA of nerve have very long chain lengths [C24, C26, C28, and C30]. The presence of these very long‐chain FFAs in endoneurium cannot be accounted for by the retention of erythrocytes or by lipid degradation. During Wallerian degeneration a significant increase of 18:1, associated with a decrease of saturated FFAs, was found in rat sciatic endoneurium, but normal values were approached when fiber regeneration was well under way. The FFA composition with chain length ≥C26were not, however, significantly altered with degeneration or repair of nerves. The metabolic significance of this striking difference between nerve and brain FFA composition is unknown but may reflect different functional properties.