FUNCTIONAL-CHANGES IN DORSAL-ROOT GANGLION-CELLS AFTER CHRONIC NERVE CONSTRICTION IN THE RAT
FUNCTIONAL-CHANGES IN DORSAL-ROOT GANGLION-CELLS AFTER CHRONIC NERVE CONSTRICTION IN THE RAT
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DOI：
10.1152/jn.1995.73.5.1811
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发表时间：
1995-05-01
影响因子：
2.5
通讯作者：
LAMOTTE, RH
中科院分区：
文献类型：
--
作者：
XIE, YK;ZHANG, JM;LAMOTTE, RH
1. 我们研究了慢性神经收缩对大鼠背根纤维对去甲肾上腺素和施加于背根神经节 (DRG) 或神经损伤部位的热刺激的诱发反应的影响。在松散结扎同侧坐骨神经后 11-52 天，我们从大鼠 L(5) 背根记录了总共 59 根 C 纤维、15 根 A δ 纤维和 46 根 A β 纤维。大多数纤维是通过部分起源于损伤部位和/或邻近损伤部位的自发活动（SA）的存在来识别的。此外，我们还记录了来自正常未损伤神经元背根的 20 个 C 纤维、1 个 A δ 纤维和 28 个 A β 纤维。2．在神经损伤的大鼠中，某些 C 纤维的 SA 通常会因冷却而增加，并因任一部位的加热而降低。相比之下，大多数 A β 纤维的 SA 通过加热损伤部位或 DRG 而增加。冷却 DRG 会减少 A β 纤维中的 SA，而冷却损伤部位通常没有效果。当对正常、未受伤大鼠的神经或DRG施加相同的热刺激时，任何纤维组均未引起兴奋反应。3．去甲肾上腺素（
1. We studied the effects of a chronic nerve constriction on the evoked responses in dorsal root fibers in the rat to norepinephrine and to thermal stimuli applied either to the dorsal root ganglion (DRG) or the site of nerve injury. We recorded a total of 59 C fibers, 15 A delta-fibers, and 46 A beta-fibers from the L(5) dorsal root of the rats 11-52 days after a loose ligation of the ipsilateral sciatic nerve. Most fibers were identified by the presence of spontaneous activity (SA) that originated partially at and/or proximal to the injury site. In addition, we recorded 20 C fibers, 1 A delta-fiber, and 28 A beta-fibers from the dorsal roots of normal, uninjured neurons.2. In nerve-injured rats, the SA of some C fibers was generally increased by cooling and decreased by heating either site. In contrast, the SA of most A beta-fibers was increased by heating either the injury site or the DRG. Cooling the DRG decreased SA in A beta-fibers, whereas cooling the injury site typically had no effect. Excitatory responses were not evoked in any fiber group when the same thermal stimuli were applied to the nerve or DRG tested in normal, uninjured rats.3. Norepinephrine (