Effect of phentermine on weight reduction in a pediatric weight management clinic.
Effect of phentermine on weight reduction in a pediatric weight management clinic.
复制标题
芬特明对儿科体重管理诊所减肥的影响。
DOI：
10.1038/ijo.2016.185
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Fox,CK
中科院分区：
文献类型：
--
作者：
Ryder,JR;Kaizer,A;Rudser,KD;Gross,A;Kelly,AS;Fox,CK
芬特明是成人最广泛的处方肥胖药物，但其在儿科人群中的使用研究有限。我们对在儿科体重管理诊所接受治疗的肥胖青少年进行了一项回顾性图表审查，以检查芬特明加入标准治疗（SOC）生活方式改变治疗与SOC单独治疗的减肥效果。所有接受芬特明加SOC的患者（n= 25）与仅接受SOC的对照组（n= 274）匹配。使用校正年龄、性别和基线体重指数（BMI）的广义估计方程以及置信区间和P值的稳健方差标准误估计值，评价了1、3和6个月时的差异。芬特明的使用与1个月时BMI的百分比变化相关（− 1.6%; 95%置信区间（CI）：− 2.6，− 0.6%; P= 0.001），3个月（− 2.9%; 95% CI：− 4.5，− 1.4%; P< 0.001）和6个月（− 4.1%; 95%CI：− 7.1，− 1.0%; P= 0.009），组间收缩压或舒张压无差异。与仅SOC组相比，芬特明+SOC组在所有时间点的心率均较高。这些数据表明，短期使用芬特明添加到SOC可能会提高体重减轻青少年肥胖的临床设置。
Phentermine is the most widely prescribed obesity medication in adults, yet studies of its use in the pediatric population are limited. We conducted a retrospective chart review of adolescents with obesity treated in a pediatric weight management clinic to examine the weight loss effectiveness of phentermine added to standard of care (SOC) lifestyle modification therapy versus SOC alone. All patients receiving phentermine plus SOC (n= 25) were matched with a comparison group receiving only SOC (n= 274). Differences at 1, 3 and 6 months were evaluated using generalized estimated equations adjusting for age, sex and baseline body mass index (BMI) and robust variance standard error estimates for confidence intervals and P-values. Phentermine use was associated with a greater percent change in BMI at 1 month (− 1.6%; 95% confidence interval (CI):− 2.6,− 0.6%; P= 0.001), 3 months (− 2.9%; 95% CI:− 4.5,− 1.4%; P< 0.001) and 6 months (− 4.1%; 95% CI:− 7.1,− 1.0%; P= 0.009) compared with SOC alone, with no differences in systolic or diastolic blood pressure between groups. Heart rate was higher at all time-points in the phentermine plus SOC compared with SOC-only group. These data suggest that short-term use of phentermine added to SOC may enhance weight loss in adolescents with obesity in the clinical setting.