Reversing insect adaptation to transgenic insecticidal plants
Reversing insect adaptation to transgenic insecticidal plants
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DOI：
10.1098/rspb.2001.1689
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发表时间：
2001-07-22
影响因子：
4.7
通讯作者：
Tabashnik, BE
中科院分区：
文献类型：
--
作者：
Carrière, Y;Tabashnik, BE
避难所-高剂量策略用于推迟昆虫对转基因植物的适应，产生能够使易感个体存活的非转基因植物。以前的理论工作提出了避难所-高剂量策略成功的三个条件：抗性等位基因的低初始频率，抗性成虫和敏感成虫之间的广泛交配，以及抗性的隐性遗传。为了更好地理解观察到的抗性频率的下降和提高抗性管理的潜力，我们使用分析和模拟模型来探索阻止或逆转抗性进化的条件，即使在最初假定随机交配的抗性并不罕见以及抗性的隐性或近隐性遗传的情况下，有利于抗性逆转的因素是非隐性抗性成本、低初始抗性等位基因频率、大避难所、不完全抗性和避难所中密度无关的种群增长。
The refuge-high-dose strategy for delaying insect adaptation to transgenic plants produces non-transgenic plants that enable survival of susceptible individuals. Previous theoretical work has suggested three requirements for success of the refuge-high-dose strategy: a low initial frequency of the resistance allele, extensive mating between resistant and susceptible adults and recessive inheritance of resistance. In order to understand an observed decrease in resistance frequency and improve the potential for managing resistance better, we used analytical and simulation models for exploring the conditions that prevent or reverse the evolution of resistance, even when resistance is not rare initially Assuming random mating and recessive or nearly recessive inheritance of resistance, the factors favouring reversal of resistance are non-recessive costs of resistance, low initial resistance allele frequency, large refuges, incomplete resistance and density-independent population growth in refuges.