STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases
STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases
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DOI：
10.1128/mcb.11.1.568-572.1991
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发表时间：
1991-01
影响因子：
5.3
通讯作者：
B. Howell;D. Afar;J. Lew;'. E. M. J. Douville;P. L. Icely;D. Gray;J. C. Bell
中科院分区：
文献类型：
--
作者：
B. Howell;D. Afar;J. Lew;'. E. M. J. Douville;P. L. Icely;D. Gray;J. C. Bell
我们从胚胎癌细胞系中克隆了一种新的激酶（STY）。STY cDNA的序列分析表明，它与丝氨酸/苏氨酸型激酶具有序列同源性，但STY cDNA的细菌表达产物似乎具有丝氨酸、苏氨酸和酪氨酸磷酸化活性。预测的STY蛋白是高度碱性的，并且含有推定的核定位信号。在分化过程中，除了胚胎转录本外，还检测到两种新的mRNA。
We have cloned a novel kinase (STY) from an embryonal carcinoma cell line. Sequence analysis of the STY cDNA reveals that it shares sequence homology with serine/threonine-type kinases and yet the bacterial expression product of the STY cDNA appears to have serine-, threonine-, and tyrosine-phosphorylating activities. The predicted STY protein is highly basic and contains a putative nuclear localization signal. During differentiation, two new mRNAs were detected in addition to the embryonic transcript.