TARGETING CANCER MICROMETASTASES WITH MONOCLONAL-ANTIBODIES - A BINDING-SITE BARRIER
TARGETING CANCER MICROMETASTASES WITH MONOCLONAL-ANTIBODIES - A BINDING-SITE BARRIER
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DOI：
10.1073/pnas.92.19.8999
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发表时间：
1995-09-12
影响因子：
11.1
通讯作者：
WEINSTEIN, JN
中科院分区：
文献类型：
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作者：
SAGA, T;NEUMANN, RD;WEINSTEIN, JN
单克隆抗体在静脉内给药后很难穿透大的肿瘤，部分原因是与靶抗原的特异性结合。这里提出的实验证明了一个类似的现象，在微转移;穷人的抗体渗透，归因于“结合位点屏障”的现象，可以看到在豚鼠微转移小至300 μ m的直径。增加抗体的剂量可以部分克服这种限制，但以特异性为代价。
Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a ''binding-site barrier'' phenomenon, can be seen in guinea pig micrometastases as small as 300 mu m in diameter. Increasing the dose of antibody can partially overcome this limitation, but at a cost in specificity.