Sex steroid hormones enhance hypotensive effects of calcitonin gene-related peptide in aged female rats
Sex steroid hormones enhance hypotensive effects of calcitonin gene-related peptide in aged female rats
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DOI：
10.1095/biolreprod.102.007682
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发表时间：
2002-12-01
影响因子：
3.6
通讯作者：
Yallampalli, C
中科院分区：
文献类型：
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作者：
Gangula, PRR;Wimalawansa, SJ;Yallampalli, C
本研究的目的是研究类固醇激素对老年雌性大鼠的血管保护作用是否通过降钙素基因相关肽（CGRP）介导，CGRP是一种已知的有效血管扩张剂。这个大鼠模型反映了人类绝经后的状态。我们研究了在给予类固醇激素治疗时，老年雌性大鼠CGRP的降血压作用是否增强。我们观察到：1)连续输注CGRP降低雌二醇-17 β和孕酮处理大鼠的血压（P < 0.05）； 2)类固醇激素组CGRP的急性降压作用显著（P < 0.05）大于车辆处理组；3)老年雌性大鼠CGRP的血压下降反应低于年轻成年去卵巢大鼠。4)用类固醇激素治疗后，CGRP的降压作用与年龄相关的差异被消除。这些数据表明，雌性类固醇激素可能通过调节CGRP效应系统来调节动脉血压，而与年龄无关。
The aim of the present study is to investigate whether vascular protective effects of steroid hormones in aged female rats are mediated through calcitonin gene-related peptide (CGRP), a known potent vasodilator. This rat model reflects the postmenopausal state in humans. We examined whether blood pressure lowering effects of CGRP are enhanced in aged female rats when steroid hormone treatments are administered. We observed that 1) continuous infusion of CGRP lowered blood pressures in rats treated with estradiol-17beta and progesterone (P < 0.05), 2) acute hypotensive effects of CGRP were significantly (P < 0.05) greater in the presence of steroid hormones than in vehicle-treated groups, 3) blood pressure decreases in response to CGRP are lower in aged female rats than they are in young adult ovariectomized rats, and 4) age-related differences in the hypotensive effects of CGRP were nullified when animals were treated with steroid hormones. These data suggest that female sex steroid hormones may modulate arterial blood pressure by regulating the CGRP effector system in female rats regardless of age.