Regulation of HMG-CoA reductase activity in plants.
Regulation of HMG-CoA reductase activity in plants.
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DOI：
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发表时间：
1994-07
影响因子：
6.5
通讯作者：
B. Stermer;G. M. Bianchini;K. L. Korth;Stermer;G. M. Bianchini;K. L. Korth;Regula
中科院分区：
文献类型：
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作者：
B. Stermer;G. M. Bianchini;K. L. Korth;Stermer;G. M. Bianchini;K. L. Korth;Regula
本文对植物中HMG-CoA还原酶（HMGR）调控的研究进展进行了综述。甲羟戊酸途径从HMGR合成甲羟戊酸开始，在植物中比在大多数其他生物中有更多的分支途径，导致种类繁多的类异戊二烯产物。有证据表明，HMGR是许多植物类异戊二烯合成的重要控制点，包括一些对初级代谢和害虫抗性至关重要的物质。植物HMGR活性在体内响应多种发育和环境信号，如细胞分裂、光和感染。植物通过对HMGR基因家族成员的差异诱导和翻译后的酶修饰在mRNA水平上调控HMGR活性。钙、钙调素和蛋白水解降解也可能在植物HMGR的调节中起作用。
This brief review summarizes the current literature on the regulation of HMG-CoA reductase (HMGR) in plants. The mevalonate pathway, which starts with the synthesis of mevalonate by HMGR, has more branch pathways in plants than in most other organisms, leading to a tremendous variety of isoprenoid products. Evidence suggests that HMGR is an important control point for the synthesis of many of these plant isoprenoids, including some that are vital for primary metabolism and pest resistance. Plant HMGR activity responds in vivo to a variety of developmental and environmental signals, such as cell division, light, and infection. Plants regulate HMGR activity at the level of mRNA by differential induction of HMGR gene family members, and posttranslationally by enzyme modification. Calcium, calmodulin, and proteolytic degradation may also have a role in regulation of plant HMGR.