Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats.
Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats.
复制标题
salusin beta 的中枢阻断可减轻自发性高血压大鼠的高血压和下丘脑炎症
DOI：
10.1038/srep11162
复制
发表时间：
2015-07-29
影响因子：
4.6
通讯作者：
Kang YM
中科院分区：
文献类型：
--
作者：
Li HB;Qin DN;Cheng K;Su Q;Miao YW;Guo J;Zhang M;Zhu GQ;Kang YM
Salusinβ是一种多功能生物活性多肽，被认为是预测动脉粥样硬化性心血管疾病的潜在候选生物标志物。本研究旨在探讨下丘脑室旁核Salusinβ对高血压和下丘脑炎症的降压作用及其机制，以及阻断中枢Salusinβ对高血压是否具有保护作用。本研究选用血压正常的Wistar-京都(WKY)大鼠和自发性高血压大鼠(SHR)。分别给予特异性Salusinβ阻断剂、抗Salusinβ免疫球蛋白(SIgG)和对照Ig G(CIgG)进行2周的慢性室旁核注射。高血压大鼠与正常血压大鼠相比，Salusinβ的表达显著增加。中枢阻断Salusinβ可降低高血压大鼠的血压，降低循环去甲肾上腺素(NE)水平，改善心肌肥厚和功能。Salusinβ阻断可显著降低高血压大鼠室旁核中促炎症细胞因子(PIC)、核因子-kappaB(NF-κB)活性、活性氧(ROS)水平和肾素-血管紧张素系统(RAS)含量。以上结果提示，阻断Salusinβ对高血压的有益作用可能是通过下调下丘脑室旁核中的炎症分子和ROS来实现的。
Salusin β is a multifunctional bioactive peptide and is considered as a promising candidate biomarker for predicting atherosclerotic cardiovascular diseases. The present study was designed to investigate the roles and mechanisms of salusin β in the paraventricular nucleus (PVN) in attenuating hypertension and hypothalamic inflammation and whether central salusin β blockade has protective effects in essential hypertension. Normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were used in this study. The rats were chronic PVN infusion either specific salusin β blocker, antisalusin β IgG (SIgG), or control IgG (CIgG) for 2 weeks. Hypertensive rats had significantly increased salusin β expression compared with normotensive rats. Central blockade of salusin β attenuated hypertension, reduced circulating norepinephrine (NE) levels, and improved cardiac hypertrophy and function in hypertensive rats. Salusin β blockade significantly reduced proinflammatory cytokines (PICs), nuclear factor-kappa B (NF-κB) activity, reactive oxygen species (ROS) levels, and altered renin-angiotensin system (RAS) components in the PVN of hypertensive rats. These findings suggest that the beneficial effects of salusin β blockade in essential hypertension are possibly due to down-regulate of inflammatory molecules and ROS in the PVN.