Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients
Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients
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DOI：
10.1161/01.hyp.0000103868.45064.81
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发表时间：
2004-01-01
期刊：
影响因子：
8.3
通讯作者：
Panza, JA
中科院分区：
文献类型：
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作者：
Cardillo, C;Campia, U;Panza, JA
高血压患者内皮素-1依赖性血管收缩张力增加。然而，这种异常可能并不均匀地存在于所有形式的高血压中，正如实验研究所表明的那样，内皮素-1活性主要在低肾素、高容量模型和胰岛素抵抗状态中增强。由于肥胖者的高血压通常与血浆容量增加和胰岛素抵抗相关，本研究试图确定高血压患者的体重指数（BMI）增加是否与内皮素-1系统的激活有关。根据BMI分析了高血压患者和血压正常对照受试者对动脉内输注ETA受体阻滞剂（BQ-123）的前臂血流（FBF）反应（体积描记法）。高血压患者对BQ-123的舒张反应显著高于对照组（P
Hypertensive patients have increased endothelin-1-dependent vasoconstrictor tone. This abnormality, however, might not be uniformly present in all forms of hypertension, as suggested by experimental studies showing that endothelin-1 activity is enhanced predominantly in low-renin, high-volume models and in insulin-resistant states. Because hypertension in obesity is commonly associated with both expanded plasma volume and insulin resistance, this study sought to determine whether increased body mass index (BMI) in hypertensive patients relates to activation of the endothelin-1 system. Forearm blood flow (FBF) responses ( plethysmography) to intra-arterial infusion of an ETA receptor blocker (BQ-123) were analyzed in hypertensive patients and normotensive control subjects according to BMI. The vasodilator response to BQ-123 was significantly higher in hypertensive patients than in control subjects (P