Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control.
Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control.
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DOI：
10.1021/bm701390f
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发表时间：
2008-03
影响因子：
6.2
通讯作者：
T. T. Reddy-T.;Arihiro Kano;A. Maruyama;Michiko Hadano;A. Takahara
中科院分区：
文献类型：
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作者：
T. T. Reddy-T.;Arihiro Kano;A. Maruyama;Michiko Hadano;A. Takahara
由嵌段聚氨酯脲/聚（N-异丙基丙烯酰胺）（SPUU/ PNiPAAm）组成的温敏、透明、柔性半互穿聚合物网络（semi-IPNs）是一类新型材料，有望用作伤口敷料。采用红外光谱、核磁共振、动态粘弹谱、广角X射线衍射和力学性能等手段对NiPAAm热引发聚合得到的一系列半互穿聚合物网络进行了表征。所得到的半互穿聚合物网络还研究了它们的动态水接触角，热力学相互作用参数，在体外药物释放，和细胞粘附和脱离。具有不同组成的半互穿网络在干燥和水合状态下都具有良好的机械性能。此外，NIH 3 T3成纤维细胞可以在不同温度下附着到这些半IPN膜上和从其上脱离。此外，这些薄膜浸提液未显示出显著的细胞毒性。因此，这些材料在构建新一代敷料和用于伤口愈合的细胞移植方面具有巨大潜力。
Thermosensitive, transparent, and flexible semi-interpenetrating polymer networks (semi-IPNs) composed of segmented polyurethane urea/poly(N-isopropylacrylamide) (SPUU/ PNiPAAm) were new class of materials, which holds promise for its potential use as wound dressings. A series of semi-IPNs, obtained via thermal initiated polymerization of NiPAAm, were characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), dynamic viscoelastic measurements, wide-angle X-ray diffraction (WAXD), and mechanical properties. The resulting semi-IPNs were also investigated for their dynamic water contact angles, thermodynamic interaction parameters, in vitro drug release, and cell adhesion and detachment. The semi-IPNs with differing compositions possess good mechanical properties in both dry and hydrated states. In addition, NIH3T3 fibroblasts can attach to and detach from these semi-IPN films with varying temperature. In addition, these film extracts do not show significant cytotoxicity. Therefore, these materials have great potential for the construction of a new generation of dressings and cell transplantation for wound healing.