ALLOANTIGEN RECOGNITION BY 2 HUMAN NATURAL-KILLER-CELL CLONES IS ASSOCIATED WITH HLA-C OR A CLOSELY LINKED GENE
ALLOANTIGEN RECOGNITION BY 2 HUMAN NATURAL-KILLER-CELL CLONES IS ASSOCIATED WITH HLA-C OR A CLOSELY LINKED GENE
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DOI：
10.1073/pnas.89.17.7983
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发表时间：
1992-09-01
影响因子：
11.1
通讯作者：
VIALE, O
中科院分区：
文献类型：
--
作者：
COLONNA, M;SPIES, T;VIALE, O
具有CD 3-CD 16+表型的人自然杀伤（NK）细胞识别正常T细胞原始细胞上的同种特异性。NK特异性1（NK-1）是一种可重复遗传的特异性抗原，定位于补体基因簇和HLA-A之间的主要组织相容性复合体。然而，NK-1的基因尚未被鉴定。在这里，我们证明了NK-1和最近定义的NK特异性2（NK-2）与HLA-C的假定肽结合位点的氨基酸位置77和80处的双等位基因多态性的纯合性无关（P < 10（-5））。因此，NK细胞对同种异体细胞的识别可能受HLA-C本身或紧密连锁的基因控制，这些基因主要阻止（抗性等位基因）或重新允许（易感性等位基因）识别仍然未知的靶决定簇。
Human natural killer (NK) cells with the CD3- CD16+ phenotype recognize allospecificities on normal T-cell blasts. The NK-defined specificity 1 (NK-1) is recessively inherited and has been mapped to the major histocompatibility complex between the complement gene cluster and HLA-A. A gene for NK-1, however, has not been identified. Here we demonstrate that NK-1 and the recently defined NK specificity 2 (NK-2) are reciprocally associated with homozygosity for a diallelic polymorphism at amino acid positions 77 and 80 in the putative peptide-binding site of HLA-C (P < 10(-5)). NK-cell recognition of allogeneic cells may, therefore, be controlled by HLA-C itself or by a closely linked gene(s), which dominantly prevents (resistance alleles) or recessively permits (susceptibility alleles) recognition of still-unknown target determinants.