Roll tilt psychophysics in rhesus monkeys during vestibular and visual stimulation.
Roll tilt psychophysics in rhesus monkeys during vestibular and visual stimulation.
复制标题
恒河猴在前庭和视觉刺激期间的滚动倾斜心理物理学。
DOI：
10.1152/jn.01012.2007
复制
发表时间：
2008
影响因子：
2.5
通讯作者：
Merfeld,DanielM
中科院分区：
文献类型：
--
作者：
Lewis,RichardF;Haburcakova,Csilla;Merfeld,DanielM
大脑是如何计算头部相对于重力的空间方向的？心理物理测量是研究这个问题的关键，但这种测量仅限于人类。在非人类灵长类动物中，行为测量集中在前庭介导的眼球运动上，这并不反映对头部方向的感知。因此，我们开发了一种方法来测量猴子的倾斜感知，源自主观视觉垂直（SVV）任务。两只恒河猴接受训练，使光条与重力平行，并在滚动倾斜、离心和滚动光动力刺激中完成这项任务。猴子在静态滚动倾斜时准确地将灯条与重力对齐，但也表现出与倾斜角度有关的小方向错误，类似于人类的测量结果。当重力惯性力（GIF）在滚转平面上动态旋转时，在头部滚转倾斜时（存在共面管旋转提示），SVV响应保持与GIF紧密对齐，在变半径离心时（没有管提示），SVV响应略微滞后于GIF，在固定半径离心时（存在正交偏航管提示），SVV响应逐渐偏移。在滚动光动力刺激下，SVV响应也偏离了地面垂直方向。这些结果表明，来自半圆管和视觉系统的旋转信号对恒河猴的滚动倾斜度的心理物理测量有显著影响，因此表明重力感觉和旋转信号的中枢合成有助于非人类灵长类动物对相对于重力的头部方向的感知。
How does the brain calculate the spatial orientation of the head relative to gravity? Psychophysical measurements are critical to investigate this question, but such measurements have been limited to humans. In non-human primates, behavioral measures have focused on vestibular-mediated eye movements, which do not reflect percepts of head orientation. We have therefore developed a method to measure tilt perception in monkeys, derived from the subjective visual vertical (SVV) task. Two rhesus monkeys were trained to align a light bar parallel to gravity and performed this task during roll tilts, centrifugation, and roll optokinetic stimulation. The monkeys accurately aligned the light bar with gravity during static roll tilts but also demonstrated small orientation-dependent misperceptions of the tilt angle analogous to those measured in humans. When the gravito-inertial force (GIF) rotated dynamically in the roll plane, SVV responses remained closely aligned with the GIF during roll tilt of the head (coplanar canal rotational cues present), lagged slightly behind the GIF during variable-radius centrifugation (no canal cues present), and shifted gradually during fixed-radius centrifugation (orthogonal yaw canal cues present). SVV responses also deviated away from the earth-vertical during roll optokinetic stimulation. These results demonstrate that rotational cues derived from the semicircular canals and visual system have prominent effects on psychophysical measurements of roll tilt in rhesus monkeys and therefore suggest that a central synthesis of graviceptive and rotational cues contributes to percepts of head orientation relative to gravity in non-human primates.