Auditory event-related potential indices of increased distractibility in children with major depression
Auditory event-related potential indices of increased distractibility in children with major depression
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DOI：
10.1016/j.clinph.2003.10.020
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发表时间：
2004-03-01
影响因子：
4.7
通讯作者：
Aronen, ET
中科院分区：
文献类型：
--
作者：
Lepistö, T;Soininen, M;Aronen, ET
目的：重度抑郁症患儿表现为短期记忆和注意力缺陷。使用听觉事件相关电位（ERPs），我们的目的是确定这些问题是否可能是由听觉感觉记忆功能障碍引起的，注意定向，或者两者兼而有之。方法：研究对象为10例初治MD患儿和10例对照组。在儿童观看无声视频时，通过扬声器播放由频繁刺激（音节/ka/， P = 0.08）、不频繁的异常刺激（音节/ta/， P = 0.01）和新奇声音（P = 0.01）组成的声音序列，而忽略声音刺激。通过诱发erp错配负性（MMN）和后期判别负性（LDN）来研究听觉感觉记忆，并以P3a作为非自愿注意转换的指标。结果：MD患儿MMN和LDN潜伏期均短于对照组。与对照组相比，患者P3a晚期成分（IP3a）振幅增强。结论：听觉感觉记忆在MD患儿中似乎功能正常。然而，ERP结果表明这些患儿的感觉敏感性和注意力分散能力增强。这种增加的注意力分散可能是影响MD患儿学习表现的集中困难的基础。(C) 2003国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: Children with major depression (MD) exhibit short-term memory and concentration deficits. Using auditory event-related potentials (ERPs), we aimed to determine whether these problems could be caused by a dysfunction in auditory sensory memory, attentional orienting, or both.Methods: The subjects were 10 treatment-naive children with MD and 10 controls. Sound sequences, consisting of frequent stimuli (syllable /ka/, P = 0.08), infrequent deviant stimuli (/ta/, P = 0.01), and novel sounds (P = 0.01) were played through loudspeakers while the children watched silent videos and ignored the sound stimuli. Auditory sensory memory was studied by eliciting the ERPs mismatch negativity (MMN) and late discriminative negativity (LDN), and the P3a was used as an index of involuntary attention switch.Results: The children with MD had shorter MMN and LDN latencies than the controls. The late component of the P3a (IP3a) was enhanced in amplitude in the patients as compared with that in the controls.Conclusions: Auditory sensory memory appears to function normally in children with MD. However, the ERP findings indicated enhanced sensory sensitivity and attentional distractibility in these children. This increased distractibility might underlie the concentration difficulties that compromise school performance in children with MD. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.