Extracellular regulation of TGF-β activity in wound repair:: growth factor latency as a sensor mechanism for injury
Extracellular regulation of TGF-β activity in wound repair:: growth factor latency as a sensor mechanism for injury
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DOI：
10.1160/th04-05-0324
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发表时间：
2004-08-01
影响因子：
6.7
通讯作者：
Blakytny, R
中科院分区：
文献类型：
--
作者：
Brunner, G;Blakytny, R
生长因子的转化生长因子-β (TGF-β) 家族是伤口修复、疤痕形成和纤维化的主要调节因子。 TGF-β生物学的显着特征之一是这种生长因子作为潜在前体分泌，可以定向并储存在细胞微环境中的特定位点。潜在 TGF-β 的靶向和动员，特别是细胞外激活控制着该生长因子的生物作用。本综述将重点关注与伤口修复和疤痕相关并可能在其中发挥作用的细胞外 TGF-β 调节机制。
The transforming growth factor-beta (TGF-beta) family of growth factors are major regulators of wound repair, scar formation, and fibrosis. One of the prominent features of TGF-beta biology is the fact that this growth factor is secreted as a latent precursor, which may be directed to and stored at specific sites in the cellular microenvironment. Targeting and mobilization, and particularly extracellular activation of latent TGF-beta control the biological action of this growth factor. This review will focus on mechanisms of extracellular TGF-beta regulation relevant to and potentially operating in wound repair and scarring.