Quorum-Sensing-Regulated Bactobolin Production by Burkholderia thailandensis E264
Quorum-Sensing-Regulated Bactobolin Production by Burkholderia thailandensis E264
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DOI：
10.1021/ol902751x
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发表时间：
2010-02-19
期刊：
影响因子：
5.2
通讯作者：
Clardy, Jon
中科院分区：
文献类型：
--
作者：
Seyedsayamdost, Mohammad R.;Chandler, Josephine R.;Clardy, Jon
细菌酰基高丝氨酸内酯上调一个未知的基因簇（bta）在伯克霍尔德氏菌泰国E264产生一个未知的极性抗生素。该抗生素被鉴定为四种bactobolins的混合物。对bta簇的注释使我们能够提出菌球蛋白的生物合成方案，并揭示不寻常的酶反应以供进一步研究。
Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.