Physical and psychological symptom biomechanics in moderate to advanced heart failure.
Physical and psychological symptom biomechanics in moderate to advanced heart failure.
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DOI：
10.1097/jcn.0000000000000171
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Lee CS
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文献类型：
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作者：
Denfeld QE;Mudd JO;Gelow JM;Chien C;Hiatt SO;Lee CS
心力衰竭（HF）的客观测量与患者症状之间存在着普遍的脱节。探讨中度至晚期心力衰竭成人心脏生物力学与身心症状之间的关系。我们对两项成人心力衰竭症状研究的数据进行了二次分析。进行逐步回归模型来检查心脏生物力学（左心室舒张内径（LVIDd）、右心房压力（RAP）和心脏指数）对症状的影响。样本（n=273）的平均年龄为57±16岁，其中61%为男性，61%为III级或IV级心力衰竭。 LVIDd（β=4.22±1.63，p=0.011）、RAP（β=0.71±0.28，p=0.013）和心脏指数（β=7.11±3.19，p=0.028）与身体症状显着相关。 LVIDd（β=0.10±0.05，p=0.038）和RAP（β=0.03±0.01，p=0.039）与焦虑显着相关。抑郁症没有显着的生物力学决定因素。心脏生物力学与身体症状和焦虑相关，为成人心力衰竭症状的生物学基础提供了初步证据。
There is a common dissociation between objective measures and patient symptomatology in heart failure (HF). To explore the relationship between cardiac biomechanics and physical and psychological symptoms in adults with moderate to advanced HF. We performed a secondary analysis of data from two studies of symptoms among adults with HF. Stepwise regression modeling was performed to examine the influence of cardiac biomechanics (left ventricular internal diastolic diameter (LVIDd), right atrial pressure (RAP), and cardiac index) on symptoms. Average age of the sample (n=273) was 57±16 years,61% were male, and 61% had class III or IV HF. LVIDd (β=4.22±1.63, p=0.011), RAP (β=0.71±0.28, p=0.013), and cardiac index (β=7.11±3.19, p=0.028) were significantly associated with physical symptoms. LVIDd (β=0.10±0.05, p=0.038) and RAP (β=0.03±0.01, p=0.039) were significantly associated with anxiety. There were no significant biomechanical determinants of depression. Cardiac biomechanics were related to physical symptoms and anxiety providing preliminary evidence of the biological underpinnings of symptomatology among adults with HF.