Cogan's syndrome: Audiovestibular involvement and prognosis in 18 patients
Cogan's syndrome: Audiovestibular involvement and prognosis in 18 patients
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Cogan 综合征：18 例患者的听前庭受累及预后
DOI：
10.1288/00005537-198506000-00003
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
B. Younge
中科院分区：
文献类型：
--
作者：
T. J. Mcdonald;R. Vollertsen;B. Younge
本文回顾了在梅奥诊所治疗18名科根综合征患者的经历。通常，这种疾病始于全身症状。眼部和听觉前庭症状包括眼部不适和发红、畏光和波动感神经性耳聋伴不平衡。每例患者均有间质性角膜炎；眼部症状周期性复发，但治疗有效。13例波动性双侧感音神经性耳聋患者随后发生双侧全聋。两例单侧耳聋患者的残余听力良好。另外两名患者在接受皮质类固醇治疗后听力恢复正常。1例患者有严重眩晕，病情稳定，未见听力症状。17例患者有眩晕：11例没有迷路功能，1例前庭测试最初没有反应，但目前显示良好反应，另外5例前庭功能下降，保持稳定。如果科根综合征得到早期诊断并及时开始皮质类固醇治疗，听力可以稳定；否则，听觉功能预后较差。
The experience at the Mayo Clinic with 18 patients who had Cogan's syndrome is reviewed. Typically, the illness began with systemic symptoms. The ocular and audiovestibular symptoms included ocular discomfort and redness, photophobia, and fluctuating sensorineural deafness with imbalance. Each patient had interstitial keratitis; the ocular symptoms periodically recurred but responded to therapy. Thirteen patients who had fluctuating bilateral sensorineural deafness subsequently suffered total bilateral deafness. Two patients who are unilaterally deaf have good residual hearing. Two other patients regained hearing within normal limits after treatment with corticosteroids. No hearing symptoms were observed in one patient who had severe vertigo and whose condition is stable. Seventeen patients had vertigo: 11 have no labyrinthine function, 1 had absent responses on vestibular testing initially but currently demonstrates good responses, and the 5 others have remained stable with diminished vestibular function. If Cogan's syndrome is diagnosed early and treatment with corticosteroids is initiated promptly, hearing can be stabilized; otherwise, the prognosis for auditory function is poor.