The unfolded protein response
The unfolded protein response
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DOI：
10.1385/mb:34:2:279
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发表时间：
2006-10-01
影响因子：
2.6
通讯作者：
Schroeder, Martin
中科院分区：
文献类型：
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作者：
Schroeder, Martin
未折叠蛋白反应（UPR）是通过抑制内质网（ER）中蛋白质折叠而激活的信号转导网络。UPR协调对这种应激情况的适应性反应，包括诱导ER驻留分子伴侣和蛋白质折叠酶表达以增加ER的蛋白质折叠能力，诱导磷脂合成，减弱一般翻译，上调ER相关降解以减少ER的未折叠蛋白质负载，以及抗氧化反应。在严重或长期的ER应激时，UPR诱导细胞凋亡以从生物体或群体中消除不健康的细胞。在这篇综述中，我将总结我们目前的知识有关的信号转导通路参与未折叠的蛋白质信号转导从ER到细胞核或胞质溶胶。
The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER). The UPR coordinates adaptive responses to this stress situation, including induction of ER resident molecular chaperone and protein foldase expression to increase the protein folding capacity of the ER, induction of phospholipid synthesis, attenuation of general translation, and upregulation of ER-associated degradation to decrease the unfolded protein load of the ER, and an antioxidant response. Upon severe or prolonged ER stress the UPR induces apoptosis to eliminate unhealthy cells from an organism or a population. In this review, I will summarize our current knowledge about signal transduction pathways involved in transducing the unfolded protein signal from the ER to the nucleus or the cytosol.