The LPA receptors
The LPA receptors
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DOI：
10.1016/s0090-6980(01)00105-8
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发表时间：
2001-04-01
影响因子：
2.9
通讯作者：
Chun, J
中科院分区：
文献类型：
--
作者：
Fukushima, N;Chun, J
溶血磷脂酸(LPA)是一种生长因子样脂类物质，可产生多种细胞反应。这些反应，包括肌动蛋白细胞骨架重排、细胞增殖和抑制缝隙连接通讯，在过去20年中在许多类型的细胞中都有报道。非受体和受体介导的机制都被用来解释这些反应。4在LPA受体的克隆和功能鉴定方面取得了明显的进展，目前有三个高亲和力成员，LPA1，LPA2和LPA3(分别与孤儿受体名称EDG-2，EDG-4和EDG-7同义)。本文就LPA受体的基因结构、表达和功能作一综述。我们还基于对神经系统的研究，讨论了单一LPA受体类型在体内的作用，神经系统是LPA受体表达的主要部位。(C)2001 Elsevier Science Inc.保留所有权利。
Lysophosphatidic acid (LPA) is a growth factor-like lipid that produces many cellular responses. These responses, including actin cytoskeletal rearrangements, cell proliferation and inhibition of gap junction communication, have been documented in many cell types over the last 2 decades. Both non-receptor and receptor-mediated mechanisms had been implicated to explain these responses. 4 clear advance in this field was the cloning and functional identification of LPA receptors, and there are currently three high-affinity members, LPA1, LPA2 and LPA3 (synonymous with orphan receptor names edg-2, edg-4 and edg-7, respectively). Here we review the gene structure, expression and functions of LPA receptors. We also discuss the in vivo roles mediated by a single LPA receptor type, based on studies of the nervous system, a major locus of LPA receptor expression. (C) 2001 Elsevier Science Inc. All rights reserved.