Chromatin learns to behave
Chromatin learns to behave
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DOI：
10.4161/epi.4.1.7604
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发表时间：
2009-01-01
期刊：
影响因子：
3.7
通讯作者：
Riccio, Antonella
中科院分区：
文献类型：
--
作者：
Crepaldi, Luca;Riccio, Antonella
表观遗传变化通常被认为是染色质的稳定修饰，它定义了细胞在发育过程中的分化状态。然而，在中枢神经系统内，染色质不是静态的，而是充当高度动态的支架，支持完全分化的有丝分裂后神经元的功能可塑性。在本综述中，我们讨论了相关研究，这些研究表明特定的染色质重塑事件如何为编码环境刺激提供基础，从而表达相关的行为反应。这已在生理和病理条件下得到证明，包括认知和药物成瘾。在染色质修饰中，组蛋白乙酰化似乎在行为调节中发挥着关键作用，使得组蛋白乙酰化酶和脱乙酰酶成为多种神经系统疾病药物治疗的有希望的候选者。
Epigenetic changes are commonly considered stable modifications of the chromatin that define the differentiation state of cells during the development. Within the central nervous system however, chromatin is not static, but acts as a highly dynamic scaffold that supports the functional plasticity of fully differentiated, post-mitotic neurons. In the present review, we discuss relevant studies that have shown how specific chromatin remodeling events provide the basis to encode environmental stimuli and, consequently, express associated behavioral responses. This has been demonstrated for both physiological and pathological conditions, including cognition and drug addiction. Among chromatin modifications, histone acetylation appears to play a pivotal role in the regulation of behavior, making histone acetylases and deacetylases promising candidates for the pharmacological treatment of several neurological disorders.