Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial.
Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial.
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DOI：
10.1016/j.conctc.2017.03.002
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发表时间：
2017-06
影响因子：
1.5
通讯作者：
Buford TW
中科院分区：
文献类型：
--
作者：
Layne AS;Krehbiel LM;Mankowski RT;Anton SD;Leeuwenburgh C;Pahor M;Sandesara B;Wu SS;Buford TW
骨骼肌线粒体功能随着年龄的增长而下降，是维持老年人身体功能的关键因素。来自动物和人类的研究一直表明，运动可以改善成年早期和中期的骨骼肌线粒体功能。然而，线粒体对急性和慢性运动的适应性在晚年会减弱。因此，有必要确定能够增强老年人对运动(例如，改善线粒体呼吸、肌肉线粒体生物发生)的线粒体适应性的辅助治疗。这项研究正在调查补充白藜芦醇以达到这一目的的可能性。这项随机、双掩蔽试验的目的是评估补充白藜芦醇和全面监督锻炼计划锻炼在改善老年人身体功能方面的效果。中等功能、久坐不动的60岁≥参与者将进行24个疗程(2天/周，为期12周)的中心步行和阻力训练，并被随机分配到(1)500 mg/天白藜芦醇(2)1000 mg/天白藜芦醇或(3)安慰剂。依赖研究的结果包括1)膝关节伸肌力量的变化，2)身体功能的客观测量(例如，4米步行测试，短身体表现电池)，3)晚年生活功能和残疾测试仪评估的身体功能的主观测量，以及4)骨骼肌线粒体功能。这项研究将提供有关补充白藜芦醇与运动相结合的治疗潜力的新信息，同时通过评估参与者的安全性和参与干预的意愿来告知干预的长期临床可行性。
Skeletal muscle mitochondrial function declines with age and is a key factor in the maintenance of physical function among older adults. Research studies from animals and humans have consistently demonstrated that exercise improves skeletal muscle mitochondrial function in early and middle adulthood. However, mitochondrial adaptations to both acute and chronic exercise are attenuated in late life. Thus, there is an important need to identify adjuvant therapies capable of augmenting mitochondrial adaptations to exercise (e.g. improved mitochondrial respiration, muscle mitochondria biogenesis) among older adults. This study is investigating the potential of resveratrol supplementation for this purpose. The objective of this randomized, double-masked pilot trial is to evaluate the efficacy of resveratrol supplementation combined with a comprehensive supervised exercise program exercise for improving physical function among older adults. Moderately functioning, sedentary participants aged ≥60 years will perform 24 sessions (2 day/wk for 12 weeks) of center-based walking and resistance training and are randomly assigned to receive either (1) 500 mg/day resveratrol (2) 1000 mg/day resveratrol or (3) placebo. Study dependent outcomes include changes in 1) knee extensor strength, 2) objective measures of physical function (e.g. 4 m walk test, Short Physical Performance Battery), 3) subjective measures of physical function assessed by Late Life Function and Disability Instrument, and 4) skeletal muscle mitochondrial function. This study will provide novel information regarding the therapeutic potential of resveratrol supplementation combined with exercise while also informing about the long-term clinical viability of the intervention by evaluating participant safety and willingness to engage in the intervention.