Current models and future directions for understanding the neural circuitries of maternal behaviors in rodents.
Current models and future directions for understanding the neural circuitries of maternal behaviors in rodents.
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DOI：
10.1177/1534582305281086
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发表时间：
2005-06-01
期刊：
影响因子：
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通讯作者：
Gammie, Stephen C
中科院分区：
文献类型：
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作者：
Gammie, Stephen C
啮齿类动物的母性行为包括许多子成分，如哺乳、筑巢、舔和梳理幼崽、取回幼崽和母性攻击。因为每一种行为都涉及一种独特的运动模式，所以每一种行为都必须有一种独特的整体神经回路。在多大程度上有重叠的大脑区域和特定的神经元的每一个电路正在积极调查。本综述将首先研究重叠和单独的组件的小狗检索和母亲的侵略电路，同时检查内侧视前区（MPA）在这两种行为的核心作用。重点放在实验方法，审查将突出最近的研究结果，并提出未来的方向，了解产妇的行为调节。最后，将提供一些例子，说明为什么研究母亲行为的神经基础可以为神经科学的其他领域带来见解，如喂养，成瘾，焦虑和攻击调节。
Maternal behaviors in rodents include a number of subcomponents, such as nursing, nest building, licking and grooming of pups, pup retrieval, and maternal aggression. Because each behavior involves a unique motor pattern, a unique ensemble neural circuitry must underlie each behavior. To what extent there is overlap in terms of brain regions and specific neurons for each circuit is being actively investigated. This review will first examine overlapping and separate components of pup retrieval and maternal aggression circuitries while examining a central role for medial preoptic area (MPA) in both behaviors. With an emphasis on experimental approaches, the review will then highlight recent findings and propose future directions for understanding maternal behavior regulation. Finally, examples for why studying the neural basis of maternal behaviors can bring insights to other areas of neuroscience, such as feeding, addiction, and anxiety and aggression regulation will be provided.