ANTI-TUMOR AGENTS FROM STREPTOMYCES-ANANDII - GILVOCARCINS-V, GILVOCARCINS-M AND GILVOCARCINS-E
ANTI-TUMOR AGENTS FROM STREPTOMYCES-ANANDII - GILVOCARCINS-V, GILVOCARCINS-M AND GILVOCARCINS-E
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DOI：
10.7164/antibiotics.34.1544
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
CLARDY, J
中科院分区：
文献类型：
--
作者：
BALITZ, DM;OHERRON, FA;CLARDY, J
报道了安氏链球菌菌素V、M和E的分离和结构鉴定。采用溶剂萃取法、高效液相色谱仪、核磁共振和X-射线单晶分析等方法进行了研究。吉尔沃卡菌素V和M具有抗微生物活性，而只有吉尔沃卡菌素V具有潜在的抗肿瘤作用。
The isolation and structure elucidation of gilvocarcins V, M and E from S. anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. Gilvocarcins V and M showed antimicrobial activity while only gilvocarcin V demonstrated potential as an antitumor agent.