Preparation of the Auricularia auricular polysaccharides simulated hydrolysates and their hypoglycaemic effect.
Preparation of the Auricularia auricular polysaccharides simulated hydrolysates and their hypoglycaemic effect.
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DOI：
10.1016/j.ijbiomac.2017.08.118
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发表时间：
2018
影响因子：
8.2
通讯作者：
A. Lu;Mengen Yu;Meng Shen;Siqi Xu;Zhengqing Xu;Yongjun Zhang;Zuo Lin;Weimin Wang
中科院分区：
文献类型：
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作者：
A. Lu;Mengen Yu;Meng Shen;Siqi Xu;Zhengqing Xu;Yongjun Zhang;Zuo Lin;Weimin Wang
本文研究了从木耳干燥子实体中提取的木耳多糖模拟水解物(APSHs)的抗糖尿病作用。 APSH 以 0.15 g/kg b.w. 的剂量胃内施用 (i.g.)。链脲佐菌素 (STZ) 诱导的糖尿病雄性 SD 大鼠 7 周。结果显示，通过 APSH 给药，空腹血糖水平显着降低（p < 0.05），而 STZ 诱导的糖尿病大鼠的糖耐量显着改善，糖尿病小鼠的体重减轻也得到了预防（p < 0.05）。此外，与糖尿病对照组相比，APSH 可以增加肝糖原和胰腺胰岛素水平 (p < 0.01)，并降低血清 TG 和 LDL-C 水平 (p < 0.05)。 APSHs 对总胆固醇和 HDL-C 水平没有显着影响。 APSH由阿拉伯糖、木糖、甘露糖、葡萄糖、半乳糖和氨基葡萄糖组成，摩尔比为1.91:0.52:2.89:1.00:0.67:0.23。这些研究表明 APSH 在实验性糖尿病中发挥显着的抗糖尿病作用，从而证明了糖尿病的潜在治疗方法。
The anti-diabetic effect of theAuriculariaauricularpolysaccharides simulated hydrolysates (APSHs) obtained from the dried fruiting body ofAuricularia auricularwas studied in this paper. The APSHs were administered intragastrically (i.g.) at the dose of 0.15 g/kg b.w. to the streptozotocin (STZ) –induced diabetic male SD rats for 7 weeks. The results showed that fasting blood glucose level was significantly reduced (p < 0.05), whereas the glucose tolerance was remarkable improvement in STZ-induced diabetic rats through APSHs administration, and loss in body weight was also prevented in diabetic mice (p < 0.05). Moreover, APSHs could increase hepatic glycogen and pancreatic insulin level (p < 0.01), as well as decrease the levels of serum TG and LDL-C compared to the diabetic control group (p < 0.05). APSHs had no significant effects on the total cholesterol and HDL-C levels. APSHs were composed of arabinose, xylose, mannose, glucose, galactose and glucosamine with the molar ratio of 1.91:0.52:2.89:1.00:0.67:0.23. These studies suggest that APSHs exerts marked antidiabetic effect in experimental diabetes mellitus, thus justifying the potential treatment for diabetic mellitus.