Redox mechanisms in blood vessels
Redox mechanisms in blood vessels
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DOI：
10.1161/01.atv.0000149143.04821.eb
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发表时间：
2005-02-01
影响因子：
8.7
通讯作者：
Harrison, DG
中科院分区：
文献类型：
--
作者：
Mueller, CFH;Laude, K;Harrison, DG
活性氧参与了血管病变形成、高血压和其他血管疾病的几乎每个阶段的发病机制。我们目前正在深入了解血管壁中活性氧的重要来源，包括NADPH氧化酶、黄嘌呤氧化酶、解偶联一氧化氮合酶和线粒体来源。尽管各种活性氧具有病理作用，但一些活性氧作为重要的信号分子调节血管张力、生长和重塑。在接下来的几个月里，一系列的文章在动脉炎，血栓形成，血管生物学试图进一步阐明活性氧是如何产生的血管细胞和这些在血管内稳态的作用。这一系列的承诺，提供了一个有价值的更新有关的生物化学，分子生物学和生理学的这些重要的和迷人的分子的各种问题。
Reactive oxygen species have been implicated in the pathogenesis of virtually every stage of vascular lesion formation, hypertension, and other vascular diseases. We are currently gaining insight into important sources of reactive oxygen species in the vessel wall, including the NADPH oxidases, xanthine oxidase, uncoupled nitric oxide synthase, and mitochondrial sources. Although various reactive oxygen species have pathological roles, some serve as important signaling molecules that modulate vascular tone, growth, and remodeling. In the next several months, a series of articles in Arteriosclerosis, Thrombosis, and Vascular Biology attempt to further elucidate how reactive oxygen species are produced by vascular cells and the roles of these in vascular homeostasis. This series promises to provide a valuable update on a wide variety of issues related to the biochemistry, molecular biology, and physiology of these important and fascinating molecules.