Cardiac Neural Crest
Cardiac Neural Crest
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DOI：
10.1101/cshperspect.a036715
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发表时间：
2021-01-01
影响因子：
7.2
通讯作者：
Yamagishi, Hiroyuki
中科院分区：
文献类型：
--
作者：
Yamagishi, Hiroyuki
心脏神经嵴（CNC）细胞是来源于背神经管的多能细胞，其迁移并有助于咽弓动脉的重塑和心脏流出道（OFT）的分隔。许多分子级联调节CNC的诱导、规格、分层和迁移。从鸡消融模型到分子生物学研究的CNC的广泛分析已经探索了心脏发育和疾病的机制，特别是涉及OFT和主动脉弓（AA）系统。最近的研究更多地集中在CNC和起源于第二心脏领域（SHF）的细胞之间的相互信号传导，这对于OFT心肌的发育至关重要，为先天性心脏病（CHDs）和一些人类综合征的分子机制提供了新的见解。
Cardiac neural crest (CNC) cells are pluripotent cells derived from the dorsal neural tube that migrate and contribute to the remodeling of pharyngeal arch arteries and septation of the cardiac outflow tract (OFT). Numerous molecular cascades regulate the induction, specification, delamination, and migration of the CNC. Extensive analyses of the CNC ranging from chick ablation models to molecular biology studies have explored the mechanisms of heart development and disease, particularly involving the OFT and aortic arch (AA) system. Recent studies focus more on reciprocal signaling between the CNC and cells originated from the second heart field (SHF), which are essential for the development of the OFT myocardium, providing new insights into the molecular mechanisms underlying congenital heart diseases (CHDs) and some human syndromes.